Statements (21)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:genetic_disorder
|
| gptkbp:affects |
gptkb:BRCA1_gene
gptkb:BRCA2_gene |
| gptkbp:associatedWith |
increased risk of breast cancer
increased risk of ovarian cancer increased risk of pancreatic cancer increased risk of prostate cancer |
| gptkbp:can_be_targeted_by |
PARP inhibitors
|
| gptkbp:canBeManagedBy |
chemoprevention
increased surveillance prophylactic surgery |
| gptkbp:cause |
gptkb:hereditary_breast_and_ovarian_cancer_syndrome
|
| gptkbp:detects |
genetic testing
|
| gptkbp:discoveredBy |
gptkb:Mary-Claire_King
|
| gptkbp:firstDescribed |
1990s
|
| gptkbp:foundIn |
both men and women
|
| gptkbp:inheritance |
autosomal dominant manner
|
| gptkbp:prevalence |
gptkb:Ashkenazi_Jewish_population
|
| gptkbp:bfsParent |
gptkb:HER2-positive_breast_cancer
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
BRCA gene mutations
|