Statements (21)
Predicate | Object |
---|---|
gptkbp:instanceOf |
genetic disorder
|
gptkbp:affects |
gptkb:BRCA1_gene
gptkb:BRCA2_gene |
gptkbp:associatedWith |
increased risk of breast cancer
increased risk of ovarian cancer increased risk of pancreatic cancer increased risk of prostate cancer |
gptkbp:can_be_targeted_by |
PARP inhibitors
|
gptkbp:canBeManagedBy |
chemoprevention
increased surveillance prophylactic surgery |
gptkbp:cause |
gptkb:hereditary_breast_and_ovarian_cancer_syndrome
|
gptkbp:detects |
genetic testing
|
gptkbp:discoveredBy |
gptkb:Mary-Claire_King
|
gptkbp:firstDescribed |
1990s
|
gptkbp:foundIn |
both men and women
|
https://www.w3.org/2000/01/rdf-schema#label |
BRCA gene mutations
|
gptkbp:inheritance |
autosomal dominant manner
|
gptkbp:prevalence |
gptkb:Ashkenazi_Jewish_population
|
gptkbp:bfsParent |
gptkb:HER2-positive_breast_cancer
|
gptkbp:bfsLayer |
7
|