BRCA gene mutations

GPTKB entity

Statements (21)
Predicate Object
gptkbp:instanceOf genetic disorder
gptkbp:affects gptkb:BRCA1_gene
gptkb:BRCA2_gene
gptkbp:associatedWith increased risk of breast cancer
increased risk of ovarian cancer
increased risk of pancreatic cancer
increased risk of prostate cancer
gptkbp:can_be_targeted_by PARP inhibitors
gptkbp:canBeManagedBy chemoprevention
increased surveillance
prophylactic surgery
gptkbp:cause gptkb:hereditary_breast_and_ovarian_cancer_syndrome
gptkbp:detects genetic testing
gptkbp:discoveredBy gptkb:Mary-Claire_King
gptkbp:firstDescribed 1990s
gptkbp:foundIn both men and women
https://www.w3.org/2000/01/rdf-schema#label BRCA gene mutations
gptkbp:inheritance autosomal dominant manner
gptkbp:prevalence gptkb:Ashkenazi_Jewish_population
gptkbp:bfsParent gptkb:HER2-positive_breast_cancer
gptkbp:bfsLayer 7