Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
mutant protein
|
| gptkbp:aminoAcidChange |
Valine to Glutamic acid at position 600
|
| gptkbp:associatedWith |
gptkb:cancer
colorectal cancer melanoma |
| gptkbp:effect |
constitutive activation
|
| gptkbp:firstDescribed |
2002
|
| gptkbp:foundIn |
gptkb:human
|
| gptkbp:gene |
gptkb:BRAF
|
| https://www.w3.org/2000/01/rdf-schema#label |
BRAF V600E mutant protein
|
| gptkbp:increasesKinaseActivity |
true
|
| gptkbp:mutantResidue |
Glutamic acid
|
| gptkbp:mutationAssociatedWith |
missense mutation
V600E |
| gptkbp:mutationAtPosition |
600
|
| gptkbp:pathway |
gptkb:MAPK/ERK_pathway
|
| gptkbp:targetOfDrug |
gptkb:encorafenib
gptkb:dabrafenib gptkb:vemurafenib |
| gptkbp:UniProtID |
P15056 (variant)
|
| gptkbp:wildTypeResidue |
gptkb:Valine
|
| gptkbp:bfsParent |
gptkb:Braftovi
|
| gptkbp:bfsLayer |
6
|