Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:challenges |
leads to increased apoptosis
|
| gptkbp:clinical_trial |
biomarker for prognosis
|
| gptkbp:community |
cellular responses to stress
|
| gptkbp:discovered_by |
gptkb:Oncology
|
| gptkbp:family |
Bcl-2 family
|
| gptkbp:function |
regulates apoptosis
|
| gptkbp:genetic_studies |
associated with resistance to chemotherapy
|
| gptkbp:has_influence_on |
treatment outcomes
|
| gptkbp:has_role |
tumorigenesis
immune evasion |
| https://www.w3.org/2000/01/rdf-schema#label |
B-cell lymphoma 2 protein
|
| gptkbp:influences |
tumor growth
|
| gptkbp:initiated_by |
small molecules
caspase activation ABT-199 Bax and Bak proteins apoptosome formation |
| gptkbp:interacts_with |
pro-apoptotic proteins
|
| gptkbp:involved_in |
gptkb:neurodegenerative_diseases
cell cycle regulation cellular stress response immune response modulation cell survival signaling pathways |
| gptkbp:is_associated_with |
tumor microenvironment
tumor microenvironment interactions poor response to therapy tumor resistance mechanisms |
| gptkbp:is_expressed_in |
can be targeted for therapy
hematopoietic cells cancerous tissues upregulated in various cancers varies among different tissues various lymphoid tissues |
| gptkbp:is_involved_in |
cellular homeostasis
metabolic pathways cellular differentiation cellular signaling pathways cellular repair mechanisms cellular signaling networks cancer cell proliferation |
| gptkbp:is_known_for |
anti-apoptotic properties
|
| gptkbp:is_linked_to |
chronic diseases
disease progression tumor progression resistance to apoptosis |
| gptkbp:is_part_of |
Bcl-2 protein family
|
| gptkbp:is_recognized_as |
follicular lymphoma
|
| gptkbp:is_regulated_by |
transcription factors
|
| gptkbp:is_studied_for |
therapeutic interventions
|
| gptkbp:is_studied_in |
cancer research
clinical oncology |
| gptkbp:is_targeted_at |
gptkb:immunotherapy
clinical trials targeted therapies novel cancer therapies BH3 mimetics |
| gptkbp:location |
mitochondria
|
| gptkbp:overexpression |
linked to poor prognosis
|
| gptkbp:promoter |
gptkb:BCL2
|
| gptkbp:regulates |
cellular metabolism
mitochondrial membrane permeability |
| gptkbp:role |
inhibitor of programmed cell death
|
| gptkbp:targets |
combination therapies
|
| gptkbp:therapeutic_target_for |
gptkb:cancer_treatment
|
| gptkbp:bfsParent |
gptkb:BCL2
|
| gptkbp:bfsLayer |
8
|