|
gptkbp:instanceOf
|
immunosuppressant
purine analogue
|
|
gptkbp:approvedBy
|
1960s
|
|
gptkbp:ATCCode
|
L04AX01
|
|
gptkbp:brand
|
Azasan
Imuran
|
|
gptkbp:CASNumber
|
446-86-6
|
|
gptkbp:category
|
purine analogues
immunosuppressants
|
|
gptkbp:chemicalFormula
|
C9H7N7O2S
|
|
gptkbp:contraindication
|
pregnancy
hypersensitivity to azathioprine
|
|
gptkbp:discoveredBy
|
gptkb:Gertrude_Elion
gptkb:George_Hitchings
|
|
gptkbp:discoveredIn
|
1957
|
|
gptkbp:eliminationHalfLife
|
~5 hours
|
|
gptkbp:excretion
|
urine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Azathioprine
|
|
gptkbp:interactsWith
|
gptkb:warfarin
allopurinol
ACE inhibitors
aminosalicylates
|
|
gptkbp:legalStatus
|
expired
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits purine synthesis
suppresses T and B lymphocyte proliferation
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
277.26 g/mol
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:prodrugOf
|
6-mercaptopurine
|
|
gptkbp:PubChem_CID
|
2265
DB00993
|
|
gptkbp:riskFactor
|
increased risk of malignancy
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nausea
vomiting
hepatotoxicity
bone marrow suppression
increased risk of infection
|
|
gptkbp:UNII
|
MRK240IY2L
|
|
gptkbp:usedFor
|
gptkb:systemic_lupus_erythematosus
gptkb:Crohn's_disease
ulcerative colitis
rheumatoid arthritis
prevention of organ transplant rejection
autoimmune hepatitis
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
|
gptkbp:bfsParent
|
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|