Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activeSiteResidue |
aspartic acid residues
|
| gptkbp:catalyzes |
hydrolysis of peptide bonds
|
| gptkbp:compatibleWith |
metal ions for activity
|
| gptkbp:EC_number |
3.4.23.-
|
| gptkbp:example |
gptkb:renin
pepsin cathepsin D HIV-1 protease |
| gptkbp:family |
MEROPS peptidase family A1
|
| gptkbp:foundIn |
animals
fungi plants microorganisms stomach lysosomes |
| gptkbp:function |
protein digestion
protein processing pathogen virulence |
| https://www.w3.org/2000/01/rdf-schema#label |
Aspartic protease
|
| gptkbp:inhibitedBy |
pepstatin
|
| gptkbp:mechanismOfAction |
uses two aspartate residues for catalysis
|
| gptkbp:molecularWeight |
typically 30-50 kDa
|
| gptkbp:optimum_pH |
2-4
|
| gptkbp:requires |
acidic pH for activity
|
| gptkbp:structure |
bilobed
|
| gptkbp:bfsParent |
gptkb:Peptidase
|
| gptkbp:bfsLayer |
7
|