|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
ApoB-48
|
|
gptkbp:ApoB-48Difference
|
ApoB-48 is a truncated form produced in the intestine
|
|
gptkbp:component
|
gptkb:low-density_lipoprotein
gptkb:intermediate-density_lipoprotein
gptkb:very_low-density_lipoprotein
|
|
gptkbp:encodedBy
|
gptkb:APOB_gene
|
|
gptkbp:foundIn
|
humans
other mammals
|
|
gptkbp:fullName
|
Apolipoprotein B-100
|
|
gptkbp:function
|
lipid transport
structural protein of lipoproteins
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ApoB-100
|
|
gptkbp:length
|
4536 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_2p24.1
|
|
gptkbp:location
|
blood plasma
|
|
gptkbp:measures
|
blood tests for lipid profile
|
|
gptkbp:molecularWeight
|
~550 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:familial_hypercholesterolemia
gptkb:hypobetalipoproteinemia
|
|
gptkbp:OMIM
|
107730
|
|
gptkbp:PDB
|
6VYO
|
|
gptkbp:proteinBinding
|
gptkb:LDL_receptor
|
|
gptkbp:requires
|
assembly of LDL
assembly of VLDL
|
|
gptkbp:significance
|
marker for cardiovascular disease risk
|
|
gptkbp:synthesisType
|
liver
|
|
gptkbp:target
|
gptkb:PCSK9_inhibitors
statins
|
|
gptkbp:UniProtID
|
gptkb:P04114
|
|
gptkbp:bfsParent
|
gptkb:apolipoprotein_B_gene
gptkb:intermediate-density_lipoprotein_(IDL)
|
|
gptkbp:bfsLayer
|
8
|