|
gptkbp:instanceOf
|
peptide
|
|
gptkbp:administeredBy
|
intravenous injection
|
|
gptkbp:approved_drug
|
yes
|
|
gptkbp:CASNumber
|
gptkb:4474-91-3
|
|
gptkbp:category
|
vasoactive peptide
endocrine hormone
octapeptide
|
|
gptkbp:chemicalFormula
|
C50H71N13O12
|
|
gptkbp:discoveredBy
|
1939
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:function
|
vasoconstriction
increases blood pressure
stimulates aldosterone secretion
stimulates antidiuretic hormone (ADH) release
|
|
gptkbp:halfLife
|
<1 minute
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Angiotensin II
|
|
gptkbp:improves
|
thirst
sodium reabsorption
sympathetic activity
|
|
gptkbp:inhibitedBy
|
ACE inhibitors
angiotensin receptor blockers (ARBs)
|
|
gptkbp:MeSH_ID
|
gptkb:D000787
|
|
gptkbp:metabolism
|
aminopeptidases
|
|
gptkbp:molecularWeight
|
1046.2 g/mol
|
|
gptkbp:part_of
|
gptkb:renin-angiotensin_system
|
|
gptkbp:predecessor
|
gptkb:Angiotensin_I
|
|
gptkbp:producedBy
|
angiotensin-converting enzyme (ACE)
|
|
gptkbp:PubChem_CID
|
173304
CHEMBL1201358
DB11842
|
|
gptkbp:recipient
|
gptkb:AT1_receptor
gptkb:AT2_receptor
|
|
gptkbp:relatedTo
|
gptkb:angiotensin_I
gptkb:angiotensinogen
gptkb:angiotensin_III
gptkb:angiotensin_IV
|
|
gptkbp:role
|
heart failure
hypertension
chronic kidney disease
fluid balance
electrolyte homeostasis
|
|
gptkbp:sequence
|
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
|
|
gptkbp:UNII
|
CBX26033P9
|
|
gptkbp:usedFor
|
vasodilatory shock
|
|
gptkbp:bfsParent
|
gptkb:ANG-I
|
|
gptkbp:bfsLayer
|
7
|