Anaplastic thyroid cancer

URI: https://gptkb.org/entity/Anaplastic_thyroid_cancer
GPTKB entity
Statements (45)
Predicate Object
gptkbp:instanceOf gptkb:cancer
Malignant neoplasm
gptkbp:affectsOrgan gptkb:Thyroid_gland
gptkbp:firstDescribed 1907
gptkbp:has5YearSurvivalRate <10%
gptkbp:hasCommonSymptoms gptkb:Neck_mass
gptkb:Dyspnea
Hoarseness
Dysphagia
gptkbp:hasDiagnosticMethod Biopsy
Histopathology
Imaging (CT, MRI, ultrasound)
gptkbp:hasGenderPredilection Slightly more common in females
gptkbp:hasGeneticAlteration gptkb:TP53_mutation
BRAF mutation
TERT promoter mutation
gptkbp:hasICD-O-3Code 8021/3
gptkbp:hasMedianSurvival <6 months
gptkbp:hasMetastasisRateAtDiagnosis >50%
gptkbp:hasMetastasisSite gptkb:Brain
gptkb:Bones
Lungs
gptkbp:hasStageAtDiagnosis gptkb:Stage_IV
gptkbp:hasTypicalAgeOfOnset >60 years
gptkbp:histology Undifferentiated
https://www.w3.org/2000/01/rdf-schema#label Anaplastic thyroid cancer
gptkbp:ICD-10_code gptkb:C73
gptkbp:incidence <2% of thyroid cancers
gptkbp:isNotResponsiveTo gptkb:Radioactive_iodine
Hormone therapy
gptkbp:mortalityRate Very high
gptkbp:originatedIn gptkb:Follicular_cells
gptkbp:otherName gptkb:Undifferentiated_thyroid_carcinoma
gptkbp:prevalence Rare
gptkbp:prognosis Poor
gptkbp:riskFactor Radiation exposure
History of goiter
Older age
gptkbp:stageName gptkb:AJCC_TNM
gptkbp:treatment radiation therapy
Surgery
Chemotherapy
Targeted therapy
gptkbp:bfsParent gptkb:cancer
gptkbp:bfsLayer 4