Anaplastic thyroid cancer

URI: https://gptkb.org/entity/Anaplastic_thyroid_cancer

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:cancer gptkb:Malignant_neoplasm
gptkbp:affectsOrgan	gptkb:Thyroid_gland
gptkbp:firstDescribed	1907
gptkbp:has5YearSurvivalRate	<10%
gptkbp:hasCommonSymptoms	gptkb:Neck_mass gptkb:Dyspnea Hoarseness Dysphagia
gptkbp:hasDiagnosticMethod	Biopsy Histopathology Imaging (CT, MRI, ultrasound)
gptkbp:hasGenderPredilection	Slightly more common in females
gptkbp:hasGeneticAlteration	gptkb:TP53_mutation BRAF mutation TERT promoter mutation
gptkbp:hasICD-O-3Code	8021/3
gptkbp:hasMedianSurvival	<6 months
gptkbp:hasMetastasisRateAtDiagnosis	>50%
gptkbp:hasMetastasisSite	gptkb:Brain gptkb:Bones Lungs
gptkbp:hasStageAtDiagnosis	gptkb:Stage_IV
gptkbp:hasTypicalAgeOfOnset	>60 years
gptkbp:histology	Undifferentiated
gptkbp:ICD-10_code	gptkb:C73
gptkbp:incidence	<2% of thyroid cancers
gptkbp:isNotResponsiveTo	gptkb:Radioactive_iodine Hormone therapy
gptkbp:mortalityRate	Very high
gptkbp:originatedIn	gptkb:Follicular_cells
gptkbp:otherName	gptkb:Undifferentiated_thyroid_carcinoma
gptkbp:prevalence	Rare
gptkbp:prognosis	Poor
gptkbp:riskFactor	Radiation exposure History of goiter Older age
gptkbp:stageName	gptkb:AJCC_TNM
gptkbp:treatment	gptkb:radiation_therapy Surgery Chemotherapy Targeted therapy
gptkbp:bfsParent	gptkb:Thyroid_Cancer
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	Anaplastic thyroid cancer