|
gptkbp:instanceOf
|
gptkb:beta_blocker
gptkb:drug
|
|
gptkbp:approvalYear
|
1990
|
|
gptkbp:ATCCode
|
gptkb:C08CA01
|
|
gptkbp:bioavailability
|
60-65%
|
|
gptkbp:brand
|
gptkb:Istin
gptkb:Norvasc
Amlogard
Amlovas
|
|
gptkbp:CASNumber
|
gptkb:88150-42-9
|
|
gptkbp:chemicalFormula
|
C20H25ClN2O5
|
|
gptkbp:combines
|
gptkb:benazepril
gptkb:valsartan
gptkb:atorvastatin
gptkb:telmisartan
gptkb:olmesartan
gptkb:aliskiren
gptkb:hydrochlorothiazide
perindopril
|
|
gptkbp:contraindication
|
unstable angina
cardiogenic shock
severe hypotension
|
|
gptkbp:developedBy
|
gptkb:Pfizer
|
|
gptkbp:drugClass
|
dihydropyridine
|
|
gptkbp:eliminationHalfLife
|
30-50 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:genericAvailable
|
yes
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:liverImpairmentWarning
|
use with caution
|
|
gptkbp:mechanismOfAction
|
inhibits calcium ion influx into vascular smooth muscle and cardiac muscle
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
408.88 g/mol
|
|
gptkbp:overdoseSymptoms
|
tachycardia
bradycardia
severe hypotension
|
|
gptkbp:patentExpired
|
2007
|
|
gptkbp:pregnancyCategory
|
C (US)
B3 (Australia)
D (UK)
|
|
gptkbp:prescribes
|
adults
children over 6 years
|
|
gptkbp:proteinBinding
|
93-98%
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
edema
dizziness
fatigue
palpitations
flushing
|
|
gptkbp:usedFor
|
gptkb:angina
hypertension
coronary artery disease
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
|
gptkbp:bfsParent
|
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Amlodipine
|