Amlodipine

GPTKB entity

Statements (55)
Predicate Object
gptkbp:instanceOf gptkb:drug
beta blocker
gptkbp:approvalYear 1990
gptkbp:ATCCode gptkb:C08CA01
gptkbp:bioavailability 60-65%
gptkbp:brand gptkb:Istin
gptkb:Norvasc
Amlogard
Amlovas
gptkbp:CASNumber gptkb:88150-42-9
gptkbp:chemicalFormula C20H25ClN2O5
gptkbp:combines gptkb:benazepril
gptkb:valsartan
gptkb:atorvastatin
gptkb:telmisartan
gptkb:olmesartan
gptkb:aliskiren
gptkb:hydrochlorothiazide
perindopril
gptkbp:contraindication unstable angina
cardiogenic shock
severe hypotension
gptkbp:developedBy gptkb:Pfizer
gptkbp:drugClass dihydropyridine
gptkbp:eliminationHalfLife 30-50 hours
gptkbp:excretion urine
gptkbp:genericAvailable yes
https://www.w3.org/2000/01/rdf-schema#label Amlodipine
gptkbp:legalStatus prescription only
gptkbp:liverImpairmentWarning use with caution
gptkbp:mechanismOfAction inhibits calcium ion influx into vascular smooth muscle and cardiac muscle
gptkbp:metabolism liver
gptkbp:molecularWeight 408.88 g/mol
gptkbp:overdoseSymptoms tachycardia
bradycardia
severe hypotension
gptkbp:patentExpired 2007
gptkbp:pregnancyCategory C (US)
B3 (Australia)
D (UK)
gptkbp:prescribes adults
children over 6 years
gptkbp:proteinBinding 93-98%
gptkbp:routeOfAdministration oral
gptkbp:sideEffect edema
dizziness
fatigue
palpitations
flushing
gptkbp:usedFor hypertension
coronary artery disease
angina
gptkbp:WHOModelListOfEssentialMedicines included
gptkbp:bfsParent gptkb:Zentiva
gptkbp:bfsLayer 7