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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:A2M
gptkb:alpha-2-macroglobulin
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
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gptkbp:category
|
gptkb:protease_inhibitor
gptkb:plasma_protein
acute-phase protein
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gptkbp:discoveredBy
|
gptkb:Heinrich_Schultze
|
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gptkbp:discoveredIn
|
1950s
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gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
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gptkbp:function
|
gptkb:protease_inhibitor
inhibits thrombin
inhibits kallikrein
inhibits plasmin
inhibits trypsin
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gptkbp:gene
|
gptkb:A2M
|
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gptkbp:locatedOnChromosome
|
gptkb:chromosome_12p13.31
|
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gptkbp:location
|
gptkb:plasma
|
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gptkbp:molecularWeight
|
720 kDa (tetramer)
|
|
gptkbp:OMIM
|
103950
|
|
gptkbp:PDB
|
4ACQ
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:significance
|
elevated in liver disease
involved in Alzheimer’s disease
marker for nephrotic syndrome
|
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gptkbp:structure
|
tetramer
|
|
gptkbp:subunit
|
homotetramer
|
|
gptkbp:UniProtID
|
P01023
|
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gptkbp:bfsParent
|
gptkb:A2M
|
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gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Alpha-2-macroglobulin
|