Alpha-2-macroglobulin

GPTKB entity

Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:A2M
gptkb:alpha-2-macroglobulin
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
gptkbp:category protease inhibitor
acute-phase protein
plasma protein
gptkbp:discoveredBy gptkb:Heinrich_Schultze
gptkbp:discoveredIn 1950s
gptkbp:foundIn gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:function protease inhibitor
inhibits thrombin
inhibits kallikrein
inhibits plasmin
inhibits trypsin
gptkbp:gene gptkb:A2M
https://www.w3.org/2000/01/rdf-schema#label Alpha-2-macroglobulin
gptkbp:locatedOnChromosome gptkb:chromosome_12p13.31
gptkbp:location gptkb:plasma
gptkbp:molecularWeight 720 kDa (tetramer)
gptkbp:OMIM 103950
gptkbp:PDB 4ACQ
gptkbp:postTranslationalModification glycosylation
gptkbp:significance elevated in liver disease
involved in Alzheimer’s disease
marker for nephrotic syndrome
gptkbp:structure tetramer
gptkbp:subunit homotetramer
gptkbp:UniProtID P01023
gptkbp:bfsParent gptkb:A2M
gptkbp:bfsLayer 7