Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:abbreviation |
gptkb:AKR
|
| gptkbp:activeSiteResidue |
gptkb:tyrosine
gptkb:aspartate lysine |
| gptkbp:cofactor |
gptkb:NADH
NADPH |
| gptkbp:database |
gptkb:UniProt
gptkb:InterPro gptkb:Pfam |
| gptkbp:EC_number |
1.1.1.-
|
| gptkbp:foundIn |
gptkb:Bacteria
animals plants |
| gptkbp:function |
catalyzes reduction of aldehydes and ketones
|
| https://www.w3.org/2000/01/rdf-schema#label |
Aldo-Keto Reductase
|
| gptkbp:inhibitedBy |
epalrestat
ranirestat sorbinil tolrestat zopolrestat |
| gptkbp:involvedIn |
detoxification
steroid metabolism prostaglandin metabolism sugar metabolism |
| gptkbp:proteinFamily |
AKR1
AKR10 AKR11 AKR12 AKR2 AKR3 AKR4 AKR5 AKR6 AKR7 AKR8 AKR9 |
| gptkbp:relatedTo |
aldose reductase
dihydrodiol dehydrogenase polyol pathway prostaglandin F synthase steroid 5β-reductase |
| gptkbp:significance |
gptkb:cancer
drug resistance diabetes complications oxidative stress response |
| gptkbp:structure |
(α/β)8-barrel fold
|
| gptkbp:superfamily |
oxidoreductase
|
| gptkbp:bfsParent |
gptkb:AKR
|
| gptkbp:bfsLayer |
7
|