Acetyl-CoA carboxylase beta

URI: https://gptkb.org/entity/Acetyl-CoA_carboxylase_beta
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activatedBy dephosphorylation
gptkbp:alternativeName gptkb:ACACB
gptkb:ACC2
gptkbp:associatedWith gptkb:type_2_diabetes
gptkb:metabolic_syndrome
obesity
gptkbp:cofactor gptkb:biotin
gptkbp:EC_number 6.4.1.2
gptkbp:encodedBy gptkb:ACACB_gene
gptkbp:Entrez_Gene_ID 32
ENSG00000076555
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function catalyzes carboxylation of acetyl-CoA to malonyl-CoA
gptkbp:gene gptkb:ACACB
gptkbp:GO_term GO:0003989
https://www.w3.org/2000/01/rdf-schema#label Acetyl-CoA carboxylase beta
gptkbp:inhibitedBy TOFA
soraphen A
CP-640186
phosphorylation by AMPK
gptkbp:involves fatty acid metabolism
gptkbp:locatedOnChromosome gptkb:chromosome_12q24.11
gptkbp:location mitochondria
cytosol
gptkbp:molecularWeight ~275 kDa
gptkbp:OMIM 601557
gptkbp:orthologInMouse Acacb
gptkbp:pathway lipid metabolism
fatty acid biosynthesis
gptkbp:PDB 6G2D
gptkbp:phosphorylates gptkb:Ser221
Ser218
Ser222
gptkbp:product gptkb:malonyl-CoA
gptkbp:proteinFamily biotin-dependent carboxylases
gptkbp:RefSeq NM_001093
gptkbp:regulates gptkb:AMP-activated_protein_kinase
phosphorylation
allosteric regulation
gptkbp:substrate acetyl-CoA
gptkbp:subunit homodimer
homotetramer
gptkbp:tissue_specificity gptkb:skeletal_muscle
heart
liver
adipose tissue
gptkbp:UniProtID O00763
gptkbp:bfsParent gptkb:ACACB
gptkbp:bfsLayer 8