Acetyl-CoA carboxylase beta

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:activatedBy	dephosphorylation
gptkbp:alternativeName	gptkb:ACACB gptkb:ACC2
gptkbp:associatedWith	gptkb:type_2_diabetes gptkb:metabolic_syndrome obesity
gptkbp:cofactor	gptkb:biotin
gptkbp:EC_number	6.4.1.2
gptkbp:encodedBy	gptkb:ACACB_gene
gptkbp:Entrez_Gene_ID	32 ENSG00000076555
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	catalyzes carboxylation of acetyl-CoA to malonyl-CoA
gptkbp:gene	gptkb:ACACB
gptkbp:GO_term	GO:0003989
gptkbp:inhibitedBy	TOFA soraphen A CP-640186 phosphorylation by AMPK
gptkbp:involves	fatty acid metabolism
gptkbp:locatedOnChromosome	gptkb:chromosome_12q24.11
gptkbp:location	mitochondria cytosol
gptkbp:molecularWeight	~275 kDa
gptkbp:OMIM	601557
gptkbp:orthologInMouse	Acacb
gptkbp:pathway	lipid metabolism fatty acid biosynthesis
gptkbp:PDB	6G2D
gptkbp:phosphorylates	gptkb:Ser221 Ser218 Ser222
gptkbp:product	gptkb:malonyl-CoA
gptkbp:proteinFamily	biotin-dependent carboxylases
gptkbp:RefSeq	NM_001093
gptkbp:regulates	gptkb:AMP-activated_protein_kinase phosphorylation allosteric regulation
gptkbp:substrate	acetyl-CoA
gptkbp:subunit	homodimer homotetramer
gptkbp:tissue_specificity	gptkb:adipose_tissue gptkb:skeletal_muscle heart liver
gptkbp:UniProtID	O00763
gptkbp:bfsParent	gptkb:ACACB
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	Acetyl-CoA carboxylase beta