|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:ACC2
ACACB protein
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
obesity
|
|
gptkbp:catalyzes
|
carboxylation of acetyl-CoA to malonyl-CoA
|
|
gptkbp:cofactor
|
gptkb:biotin
|
|
gptkbp:EC_number
|
6.4.1.2
|
|
gptkbp:Entrez_Gene_ID
|
32
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
heart
liver
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
regulation of fatty acid oxidation
|
|
gptkbp:gene
|
gptkb:ACACB
|
|
gptkbp:inhibitedBy
|
gptkb:AMP-activated_protein_kinase_(AMPK)
phosphorylation
|
|
gptkbp:locatedOnChromosome
|
chromosome 12q24.1
|
|
gptkbp:location
|
mitochondria
|
|
gptkbp:molecularWeight
|
~280 kDa
|
|
gptkbp:OMIM
|
601557
|
|
gptkbp:orthologInMouse
|
Acacb
|
|
gptkbp:pathway
|
lipid biosynthesis
fatty acid metabolism
|
|
gptkbp:PDB
|
3JRW
|
|
gptkbp:phosphorylates
|
Ser218
Ser222
|
|
gptkbp:product
|
gptkb:malonyl-CoA
|
|
gptkbp:RefSeq
|
NM_001093
|
|
gptkbp:regulates
|
carnitine palmitoyltransferase 1 (CPT1) activity
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProt
|
|
gptkbp:structure
|
multi-domain protein
|
|
gptkbp:substrate
|
acetyl-CoA
|
|
gptkbp:UniProtID
|
O00763
|
|
gptkbp:bfsParent
|
gptkb:ACACB
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Acetyl-CoA carboxylase 2
|