Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
genetic risk factor |
| gptkbp:affects |
lipid metabolism
amyloid-beta aggregation |
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
|
| gptkbp:contrastsWith |
gptkb:APOE_ε2_allele
gptkb:APOE_ε3_allele |
| gptkbp:discoveredBy |
genetic studies in the 1980s
|
| gptkbp:foundIn |
gptkb:APOE_gene
|
| gptkbp:frequencyInAfricanPopulations |
~20-25%
|
| gptkbp:frequencyInEastAsianPopulations |
~7-10%
|
| gptkbp:frequencyInEuropeanPopulations |
~15%
|
| gptkbp:hasNucleotideChange |
gptkb:rs429358
gptkb:rs7412 |
| https://www.w3.org/2000/01/rdf-schema#label |
APOE ε4 allele
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_19
|
| gptkbp:numberOfCopiesIncreasesRisk |
1 copy increases risk, 2 copies increase risk further
|
| gptkbp:product |
gptkb:apolipoprotein_E4
|
| gptkbp:riskFactor |
gptkb:cardiovascular_disease
gptkb:late-onset_Alzheimer's_disease |
| gptkbp:usedIn |
genetic testing for Alzheimer's risk
|
| gptkbp:bfsParent |
gptkb:late-onset_Alzheimer's_disease
|
| gptkbp:bfsLayer |
6
|