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Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:affects |
lipid metabolism
|
| gptkbp:aminoAcidChange |
arginine at positions 112 and 158
|
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
gptkb:cardiovascular_disease |
| gptkbp:discoveredBy |
genetic studies in the 1990s
|
| gptkbp:foundIn |
humans
|
| gptkbp:frequency |
~15% worldwide
|
| gptkbp:gene |
heterozygous
homozygous |
| gptkbp:homozygousRisk |
higher than heterozygous
|
| https://www.w3.org/2000/01/rdf-schema#label |
APOE-e4 allele
|
| gptkbp:influenced |
response to brain injury
response to statin therapy |
| gptkbp:isOneOf |
APOE alleles
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_19
|
| gptkbp:mostCommonAPOEAllele |
gptkb:APOE-e3
|
| gptkbp:otherAPOEAlleles |
gptkb:APOE-e2
gptkb:APOE-e3 |
| gptkbp:riskFactor |
gptkb:late-onset_Alzheimer's_disease
cognitive decline atherosclerosis cerebral amyloid angiopathy |
| gptkbp:studiedIn |
genetic epidemiology
|
| gptkbp:usedIn |
genetic testing for Alzheimer's risk
|
| gptkbp:variant |
gptkb:APOE_gene
|
| gptkbp:bfsParent |
gptkb:Alzheimer's_disease
|
| gptkbp:bfsLayer |
4
|