|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:AP-2_complex
gptkb:Adaptor_protein_complex_2
Adaptor-related protein complex 2
|
|
gptkbp:binds
|
gptkb:clathrin
phosphoinositides
cargo proteins
|
|
gptkbp:component
|
gptkb:AP2A1
gptkb:AP2A2
gptkb:AP2B1
gptkb:AP2M1
gptkb:AP2S1
|
|
gptkbp:discoveredBy
|
1980s
|
|
gptkbp:encodedBy
|
AP2A1 gene
AP2A2 gene
AP2B1 gene
AP2M1 gene
AP2S1 gene
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
clathrin-mediated endocytosis
|
|
gptkbp:gene_ontology_ID
|
gptkb:GO:0030121
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AP-2 adaptor complex
|
|
gptkbp:interactsWith
|
gptkb:dynamin
gptkb:amphiphysin
Eps15
synaptojanin
|
|
gptkbp:involves
|
vesicle formation
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~300 kDa
|
|
gptkbp:mutationAssociatedWith
|
neurological disorders
|
|
gptkbp:PDB
|
2VGL
|
|
gptkbp:recognizedBy
|
YXXΦ motifs on cargo proteins
[DE]XXXL[LI] motifs on cargo proteins
|
|
gptkbp:recruitedFrom
|
clathrin to plasma membrane
|
|
gptkbp:regulates
|
endocytosis
|
|
gptkbp:requires
|
receptor-mediated endocytosis
synaptic vesicle recycling
|
|
gptkbp:structure
|
heterotetramer
|
|
gptkbp:studiedBy
|
cell biology
|
|
gptkbp:subunit
|
alpha-adaptin
beta2-adaptin
mu2-adaptin
sigma2-adaptin
|
|
gptkbp:UniProtID
|
O94973 (AP2A2)
Q96CW1 (AP2A1)
Q96CW2 (AP2B1)
Q96CW3 (AP2M1)
Q96CW4 (AP2S1)
|
|
gptkbp:bfsParent
|
gptkb:AP-2_complex
|
|
gptkbp:bfsLayer
|
8
|