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gptkbp:instance_of
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gptkb:DNA
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gptkbp:activator
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AMPK activator
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gptkbp:anatomy
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Liver
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gptkbp:application
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Energy homeostasis
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gptkbp:associated_with
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gptkb:Adenosine_Monophosphate
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gptkbp:biomarker_potential
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Metabolic syndrome
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gptkbp:breeding_range
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1q21.1
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gptkbp:cell_line_studies
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Hep G2 cells
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gptkbp:cell_type_specific_expression
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Hepatocytes
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gptkbp:cellular_component
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Cytoplasm
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gptkbp:clinical_trial
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Ongoing studies
Potential biomarker for diseases
Diabetes and obesity studies
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gptkbp:collaborations
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International research teams
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gptkbp:discovery_year
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gptkb:2001
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gptkbp:diseases
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gptkb:diabetes
Obesity
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gptkbp:expression_analysis
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RT-PCR studies
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gptkbp:function
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Regulates cellular metabolism
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gptkbp:functional_assay
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Kinase activity assay
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gptkbp:functional_domain
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Catalytic domain
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gptkbp:gene_expression
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Upregulated in cancer cells
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gptkbp:gene_function
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Regulates energy balance
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gptkbp:gene_mapping
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Identified in genome-wide association studies
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gptkbp:gene_therapy_potential
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Target for gene editing.
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gptkbp:genetic_disorder
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Inherited metabolic disorders
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gptkbp:genetic_diversity
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Single nucleotide polymorphisms
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gptkbp:genetic_linkage
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Chromosomal abnormalities
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gptkbp:genetic_screening
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Identified in cancer genomics
|
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gptkbp:genetic_studies
|
Metabolic disorders
Highly conserved across species
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gptkbp:genomic_size
|
2,500 base pairs
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AMU1
|
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gptkbp:initiated_by
|
AMPK inhibitor
|
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gptkbp:interacts_with
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gptkb:AMPK
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gptkbp:is_expressed_in
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Upregulated in stress conditions
|
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gptkbp:knockout_effect
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Impaired glucose tolerance
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gptkbp:located_in
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Human Chromosome 1
|
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gptkbp:modifications
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Phosphorylation
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gptkbp:molecular_pathway
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AMPK signaling pathway
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gptkbp:nutritional_value
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gptkb:Atom
gptkb:AMU1_protein
AMPK complex
AMPK family
Energy sensor
Kinase domain
|
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gptkbp:orthologous_gene
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AMU2 in mice
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gptkbp:orthologs
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gptkb:AMU2
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gptkbp:pathway
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AMP signaling pathway
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gptkbp:promoter
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gptkb:AMU1
AMPK family
GO:0004672
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gptkbp:protein_complex
|
AMPK heterotrimer
|
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gptkbp:protein_expression
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Western blot analysis
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gptkbp:protein_modification
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Ubiquitination
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gptkbp:publication
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gptkb:Journal_of_Molecular_Biology
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gptkbp:regulatory_compliance
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Insulin signaling
|
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gptkbp:related_to
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gptkb:AMP-activated_protein_kinase
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gptkbp:research
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Kinase activity
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gptkbp:research_areas
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Molecular Biology
|
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gptkbp:research_focus
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Metabolic regulation
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gptkbp:research_model
|
Mouse model
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gptkbp:role
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Cellular energy sensor
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gptkbp:seed_dispersal
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Protein-coding gene
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gptkbp:subcellular_location
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Mitochondria
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gptkbp:targets
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Diabetes treatment
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gptkbp:transcription_factor_binding
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gptkb:CREB
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