ALS (Amyotrophic Lateral Sclerosis)

URI: https://gptkb.org/entity/ALS_(Amyotrophic_Lateral_Sclerosis)
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf neurodegenerative disease
gptkbp:affects motor neurons
gptkbp:alsoKnownAs gptkb:Lou_Gehrig's_disease
gptkbp:averageAgeOfOnset 55
gptkbp:awarenessEvent gptkb:ALS_Ice_Bucket_Challenge
gptkbp:casualties yes
gptkbp:cause difficulty breathing
difficulty speaking
difficulty swallowing
muscle atrophy
muscle weakness
gptkbp:compatibleWith cognitive function (in most cases)
gptkbp:diagnosedBy MRI
clinical examination
electromyography
nerve conduction study
gptkbp:familialCases 5-10%
gptkbp:firstDescribed gptkb:Jean-Martin_Charcot
1869
gptkbp:hereditary sometimes
https://www.w3.org/2000/01/rdf-schema#label ALS (Amyotrophic Lateral Sclerosis)
gptkbp:ICD-10_code G12.2
gptkbp:incidence 2 per 100,000 per year
gptkbp:medianSurvival 2-5 years
gptkbp:MeSH_ID D000690
gptkbp:mutationAssociatedWith gptkb:C9orf72
gptkb:FUS
gptkb:SOD1
gptkb:TARDBP
gptkbp:notablePatient gptkb:Stephen_Hawking
gptkb:Lou_Gehrig
gptkbp:OMIM 105400
gptkbp:onset adult
gptkbp:prevalence 5 per 100,000
gptkbp:prognosis poor
gptkbp:progression progressive
gptkbp:relatedTo frontotemporal dementia
gptkbp:researchOrganization gptkb:ALS_Association
gptkbp:sporadicCases 90-95%
gptkbp:symptom respiratory failure
weight loss
cramps
muscle twitching
spasticity
gptkbp:treatment gptkb:edaravone
gptkb:riluzole
supportive care
gptkbp:bfsParent gptkb:स्टीफन_हॉकिंग
gptkb:Ice_Bucket_Challenge
gptkbp:bfsLayer 6