Statements (78)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:bfsLayer |
6
|
| gptkbp:bfsParent |
gptkb:alectinib
gptkb:crizotinib gptkb:Crizotinib |
| gptkbp:associated_with |
gptkb:healthcare_organization
increased cell proliferation altered gene expression increased risk of secondary malignancies brain metastases increased risk of recurrence immunotherapy response increased risk of metastasis activation of RAS pathway altered immune response crizotinib efficacy decreased overall survival increased angiogenic factors increased expression of ALK protein increased expression of growth factors increased metastatic potential increased proliferation rates increased resistance to chemotherapy increased resistance to targeted therapies increased tumor heterogeneity increased tumor invasiveness poor response to standard therapies young age at diagnosis |
| gptkbp:can_be |
chromosomal instability
alternative splicing fusion proteins tumor microenvironment changes |
| gptkbp:can_lead_to |
therapeutic resistance
drug resistance therapeutic challenges altered apoptosis pathways altered cell metabolism changes in cell cycle regulation |
| gptkbp:caused_by |
metastasis
|
| https://www.w3.org/2000/01/rdf-schema#label |
ALK gene rearrangements
|
| gptkbp:influences |
tumor growth
|
| gptkbp:is_aimed_at |
gptkb:brigatinib
gptkb:lorlatinib gptkb:alectinib gptkb:ceritinib ALK inhibitors |
| gptkbp:is_analyzed_in |
next-generation sequencing
immunohistochemistry |
| gptkbp:is_found_in |
gptkb:healthcare_organization
lymphoid tissues solid tumors various cancer types hematological malignancies |
| gptkbp:is_involved_in |
signal transduction pathways
oncogenesis |
| gptkbp:is_linked_to |
gptkb:neuroblastoma
poor prognosis increased angiogenesis increased cell survival activation of downstream signaling pathways increased cell migration altered cellular signaling differentiation of tumor cells increased expression of anti-apoptotic proteins increased expression of oncogenes increased risk of treatment failure |
| gptkbp:is_monitored_by |
gptkb:item
|
| gptkbp:is_often_depicted_as |
gptkb:lung_adenocarcinoma
|
| gptkbp:is_recognized_by |
gptkb:healthcare_organization
pediatric cancers |
| gptkbp:is_studied_in |
clinical trials
laboratory research |
| gptkbp:recognizes |
FISH analysis
tumor biopsies plasma samples circulating tumor DNA |
| gptkbp:resulted_in |
abnormal protein production
|
| gptkbp:screenings |
PCR methods
|