|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:angiotensinogen
SERPINA8
serpin family A member 8
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
kidney disease
hypertension
pre-eclampsia
|
|
gptkbp:clinicalTrialPhase
|
genetic testing for hypertension risk
|
|
gptkbp:discoveredBy
|
Jean Sealey and John Laragh
|
|
gptkbp:encodes
|
gptkb:angiotensinogen_protein
|
|
gptkbp:Entrez_Gene_ID
|
183
ENSG00000135744
rs4762
rs5050
rs699
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
liver
adipose tissue
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:fullName
|
angiotensinogen gene
|
|
gptkbp:function
|
regulation of blood pressure
precursor to angiotensin I and II
regulation of electrolyte balance
|
|
gptkbp:HGNC_ID
|
333
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AGT gene
|
|
gptkbp:length
|
13 exons
485 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
1q42.2
|
|
gptkbp:molecularWeight
|
~53 kDa
|
|
gptkbp:mutationAssociatedWith
|
can increase risk of hypertension
|
|
gptkbp:OMIM
|
106150
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Agt
|
|
gptkbp:pathway
|
gptkb:renin-angiotensin_system
|
|
gptkbp:product
|
gptkb:angiotensinogen
|
|
gptkbp:proteinFamily
|
serpin
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38.p14
|
|
gptkbp:regulates
|
hormone
inflammation
corticosteroids
estrogen
|
|
gptkbp:UniProtID
|
P01019
|
|
gptkbp:bfsParent
|
gptkb:ANG-I
gptkb:angiotensinogen
|
|
gptkbp:bfsLayer
|
7
|