|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:AC3
adenylate cyclase 3
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
obesity
|
|
gptkbp:biologicalProcess
|
ATP binding
adenylate cyclase activity
G-protein coupled receptor signaling pathway
cAMP biosynthetic process
|
|
gptkbp:cellularComponent
|
gptkb:cell_membrane
integral component of membrane
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodes
|
adenylate cyclase 3
|
|
gptkbp:Entrez_Gene_ID
|
109
ENSG00000152237
|
|
gptkbp:expressedIn
|
gptkb:olfactory_epithelium
brain
pancreas
|
|
gptkbp:fullName
|
Adenylate cyclase type 3
|
|
gptkbp:function
|
catalyzes conversion of ATP to cAMP
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:234
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ADCY3
|
|
gptkbp:length
|
21 exons
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
2p23.3
|
|
gptkbp:mutationAssociatedWith
|
early-onset severe obesity
autosomal recessive nonsyndromic olfactory dysfunction
|
|
gptkbp:OMIM
|
600291
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Adcy3
|
|
gptkbp:pathway
|
gptkb:Neuroactive_ligand-receptor_interaction
gptkb:cAMP_signaling_pathway
Olfactory transduction
|
|
gptkbp:proteinFamily
|
adenylate cyclase family
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
activated by G-protein alpha subunits
inhibited by calcium
regulated by forskolin
|
|
gptkbp:UniProtID
|
O60266
|
|
gptkbp:bfsParent
|
gptkb:adenylate_cyclase
|
|
gptkbp:bfsLayer
|
6
|