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gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:BCRP
breast cancer resistance protein
|
|
gptkbp:associatedWith
|
gout
drug resistance in cancer
pharmacokinetics of drugs
|
|
gptkbp:biologicalProcess
|
exports chemotherapeutic agents
exports uric acid
exports xenobiotics
|
|
gptkbp:discoveredBy
|
Doyle et al.
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:encodes
|
ABCG2 protein
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000118777
9429
|
|
gptkbp:expressedIn
|
gptkb:placenta
gptkb:blood-brain_barrier
liver
intestine
|
|
gptkbp:fullName
|
ATP-binding cassette sub-family G member 2
|
|
gptkbp:function
|
multidrug resistance
xenobiotic transport
transmembrane transporter
|
|
gptkbp:HGNC_ID
|
HGNC:74
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ABCG2 gene
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4
4q22.1
|
|
gptkbp:memberOf
|
gptkb:ATP-binding_cassette_(ABC)_transporter_family
|
|
gptkbp:mutationAssociatedWith
|
drug toxicity
hyperuricemia
|
|
gptkbp:OMIM
|
603756
|
|
gptkbp:orthologInMouse
|
Abcg2
|
|
gptkbp:product
|
half-transporter
|
|
gptkbp:regulates
|
gptkb:hypoxia
estrogen
nuclear receptors
|
|
gptkbp:significance
|
impacts drug bioavailability
impacts drug resistance in chemotherapy
marker for cancer stem cells
|
|
gptkbp:UniProtID
|
Q9UNQ0
|
|
gptkbp:bfsParent
|
gptkb:CD338
|
|
gptkbp:bfsLayer
|
8
|