AAV (adeno-associated virus)

URI: https://gptkb.org/entity/AAV_(adeno-associated_virus)
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:virus
parvovirus
gptkbp:abbreviation gptkb:AAV
gptkbp:application vaccine development
optogenetics
CRISPR delivery
delivery of therapeutic genes
gptkbp:approvedTherapy gptkb:Luxturna
gptkb:Zolgensma
gptkbp:biosafetyLevel 1
gptkbp:capShape icosahedral
gptkbp:containsSerotype gptkb:AAV9
AAV2
AAV1
AAV3
AAV4
AAV5
AAV6
AAV7
AAV8
AAVrh10
gptkbp:discoveredBy Bob Atchison
M. David Hoggan
gptkbp:discoveredIn 1965
gptkbp:family gptkb:Parvoviridae
gptkbp:fullName gptkb:virus
gptkbp:genomeSize ~4.7 kilobases
gptkbp:genomeType single-stranded DNA
gptkbp:genus gptkb:Dependoparvovirus
gptkbp:hasReplica requires co-infection with helper virus
gptkbp:helperVirus gptkb:virus
gptkbp:hostedBy gptkb:human
other primates
https://www.w3.org/2000/01/rdf-schema#label AAV (adeno-associated virus)
gptkbp:immuneResponse low
gptkbp:integrationFrequency low
gptkbp:integrationSite AAVS1 site on human chromosome 19
gptkbp:non-pathogenic yes
gptkbp:persistenceMechanism episomal
gptkbp:recipient galactose (AAV9)
heparan sulfate proteoglycan (AAV2)
sialic acid (AAV5)
gptkbp:requiresHelperVirus yes
gptkbp:structure non-enveloped
gptkbp:transductionEfficiency high in non-dividing cells
gptkbp:usedIn gene therapy
genetic research
gptkbp:usedInAnimalModels yes
gptkbp:vectorCapacity ~4.7 kb
gptkbp:bfsParent gptkb:SPK-9001
gptkbp:bfsLayer 8