|
gptkbp:instanceOf
|
adeno-associated virus serotype
|
|
gptkbp:administeredBy
|
intravenous injection
intrathecal injection
|
|
gptkbp:containsSerotype
|
gptkb:Adeno-associated_virus
|
|
gptkbp:crossesBloodBrainBarrier
|
true
|
|
gptkbp:discoveredBy
|
James M. Wilson
|
|
gptkbp:discoveredIn
|
2004
|
|
gptkbp:familyMember
|
gptkb:Parvoviridae
|
|
gptkbp:fullName
|
Adeno-associated virus serotype 9
|
|
gptkbp:genomeSize
|
~4.7 kb
|
|
gptkbp:genomeType
|
single-stranded DNA
|
|
gptkbp:genus
|
gptkb:Dependoparvovirus
|
|
gptkbp:hasCapsidProtein
|
gptkb:VP1
gptkb:VP2
gptkb:VP3
|
|
gptkbp:hasTropismFor
|
gptkb:skeletal_muscle
heart
central nervous system
liver
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AAV9
|
|
gptkbp:isNonPathogenic
|
true
|
|
gptkbp:isReplicationDefective
|
true
|
|
gptkbp:requiresHelperVirus
|
true
|
|
gptkbp:studiedBy
|
CNS gene delivery
cardiac gene delivery
muscle gene delivery
|
|
gptkbp:usedFor
|
treatment of Duchenne muscular dystrophy
delivery of therapeutic genes
treatment of Batten disease
treatment of Pompe disease
treatment of spinal muscular atrophy
|
|
gptkbp:usedIn
|
gptkb:Zolgensma
gene therapy
|
|
gptkbp:vectorFor
|
gptkb:virus
|
|
gptkbp:bfsParent
|
gptkb:adeno-associated_virus_serotype_9_(AAV9)
|
|
gptkbp:bfsLayer
|
6
|