|
gptkbp:instanceOf
|
gptkb:virus
|
|
gptkbp:abbreviation
|
gptkb:AAV
|
|
gptkbp:application
|
vector for gene delivery
|
|
gptkbp:capsid_symmetry
|
icosahedral
|
|
gptkbp:discoveredBy
|
Bob Atchison
M. David Hoggan
Wallace P. Rowe
|
|
gptkbp:discoveredIn
|
1965
|
|
gptkbp:does_not_cause_disease_in_humans
|
true
|
|
gptkbp:family
|
gptkb:Parvoviridae
|
|
gptkbp:genomeType
|
single-stranded DNA
|
|
gptkbp:genus
|
gptkb:Dependoparvovirus
|
|
gptkbp:hasReplica
|
requires co-infection with helper virus
|
|
gptkbp:hostedBy
|
gptkb:human
other primates
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Adeno-associated virus
|
|
gptkbp:integrates_into_host_genome
|
site-specific (AAV2)
|
|
gptkbp:non-pathogenic
|
true
|
|
gptkbp:number_of_serotypes
|
at least 12
|
|
gptkbp:requires_helper_virus
|
gptkb:virus
|
|
gptkbp:site_of_integration
|
chromosome 19 (AAVS1 site)
|
|
gptkbp:size
|
~25 nm
|
|
gptkbp:structure
|
non-enveloped
|
|
gptkbp:subfamily
|
gptkb:Parvovirinae
|
|
gptkbp:used_in
|
neuroscience research
gene therapy
optogenetics
CRISPR delivery
muscular dystrophy gene therapy
ophthalmology gene therapy
|
|
gptkbp:bfsParent
|
gptkb:AAV
gptkb:adeno-associated_virus_serotype_9_(AAV9)
|
|
gptkbp:bfsLayer
|
6
|