|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:5α-reductase_deficiency_causes
|
disorders of sexual development
|
|
gptkbp:associatedWith
|
gptkb:benign_prostatic_hyperplasia
prostate cancer
androgenetic alopecia
|
|
gptkbp:cofactor
|
NADPH
|
|
gptkbp:discoveredBy
|
1970s
|
|
gptkbp:EC_number
|
1.3.1.22
|
|
gptkbp:foundIn
|
humans
other mammals
|
|
gptkbp:function
|
catalyzes the conversion of testosterone to dihydrotestosterone (DHT)
|
|
gptkbp:gene
|
gptkb:SRD5A1
gptkb:SRD5A2
gptkb:SRD5A3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
5α-reductase
|
|
gptkbp:inhibitedBy
|
gptkb:dutasteride
gptkb:finasteride
|
|
gptkbp:location
|
gptkb:skin
gptkb:prostate
liver
reproductive tissues
|
|
gptkbp:mutationAssociatedWith
|
gptkb:5α-reductase_deficiency
|
|
gptkbp:product
|
gptkb:dihydrotestosterone
|
|
gptkbp:significance
|
target for treatment of hair loss
target for treatment of prostate disorders
|
|
gptkbp:substrate
|
testosterone
|
|
gptkbp:type
|
membrane-bound enzyme
|
|
gptkbp:bfsParent
|
gptkb:Dihydrotestosterone_(DHT)
gptkb:DHT
gptkb:dihydrotestosterone
|
|
gptkbp:bfsLayer
|
7
|