Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:5α-reductase_deficiency_causes |
disorders of sexual development
|
| gptkbp:associatedWith |
gptkb:benign_prostatic_hyperplasia
prostate cancer androgenetic alopecia |
| gptkbp:cofactor |
NADPH
|
| gptkbp:discoveredBy |
1970s
|
| gptkbp:EC_number |
1.3.1.22
|
| gptkbp:foundIn |
humans
other mammals |
| gptkbp:function |
catalyzes the conversion of testosterone to dihydrotestosterone (DHT)
|
| gptkbp:gene |
gptkb:SRD5A1
gptkb:SRD5A2 gptkb:SRD5A3 |
| gptkbp:inhibitedBy |
gptkb:dutasteride
gptkb:finasteride |
| gptkbp:location |
gptkb:skin
gptkb:prostate liver reproductive tissues |
| gptkbp:mutationAssociatedWith |
gptkb:5α-reductase_deficiency
|
| gptkbp:product |
gptkb:dihydrotestosterone
|
| gptkbp:significance |
target for treatment of hair loss
target for treatment of prostate disorders |
| gptkbp:substrate |
testosterone
|
| gptkbp:type |
membrane-bound enzyme
|
| gptkbp:bfsParent |
gptkb:DHT
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
5α-reductase
|