Statements (45)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
CD73
ecto-5'-nucleotidase |
| gptkbp:associatedWith |
purine metabolism
|
| gptkbp:catalyzes |
hydrolysis of 5'-nucleotides to nucleosides and phosphate
|
| gptkbp:EC_number |
3.1.3.5
|
| gptkbp:expressedIn |
endothelial cells
epithelial cells lymphocytes |
| gptkbp:foundIn |
gptkb:cell_membrane
gptkb:kidney brain heart liver cytosol blood serum |
| gptkbp:gene |
NT5E
|
| https://www.w3.org/2000/01/rdf-schema#label |
5'-nucleotidase
|
| gptkbp:inhibitedBy |
gptkb:ATP
gptkb:ADP inorganic phosphate |
| gptkbp:molecularWeight |
~70 kDa
|
| gptkbp:product |
gptkb:guanosine
gptkb:adenosine phosphate inosine |
| gptkbp:requires |
Mg2+
Zn2+ |
| gptkbp:role |
angiogenesis
immunomodulation cell adhesion tumor progression inflammation control regulation of extracellular adenosine levels vascular homeostasis |
| gptkbp:significance |
differentiates liver from bone disease
elevated in cholestatic liver disease |
| gptkbp:structure |
gptkb:protein
|
| gptkbp:substrate |
gptkb:GMP
gptkb:IMP gptkb:AMP |
| gptkbp:usedFor |
biomarker for liver function
|
| gptkbp:bfsParent |
gptkb:adenosine_5'-monophosphate
gptkb:5'-AMP |
| gptkbp:bfsLayer |
7
|