Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
NMDA receptor antagonist antitussive dissociative drug |
| gptkbp:abusePotential |
yes
|
| gptkbp:ATCCode |
R05DA09
|
| gptkbp:brand |
gptkb:Coricidin
gptkb:Delsym gptkb:NyQuil gptkb:Robitussin gptkb:Vicks_44 |
| gptkbp:CASNumber |
125-71-3
|
| gptkbp:chemicalFormula |
C18H25NO
|
| gptkbp:chirality |
dextrorotatory
|
| gptkbp:combines |
bupropion (for depression)
quinidine (for pseudobulbar affect) |
| gptkbp:developedBy |
gptkb:Hoffmann-La_Roche
|
| gptkbp:discoveredBy |
1953
|
| gptkbp:eliminationHalfLife |
3–6 hours
|
| gptkbp:excretion |
urine
|
| gptkbp:hasInChIKey |
MKXZASYAUGDDCJ-UHFFFAOYSA-N
|
| gptkbp:hasSMILES |
COc1ccc2CC3CCN(C)CC3c2c1
|
| https://www.w3.org/2000/01/rdf-schema#label |
(+)-dextromethorphan
|
| gptkbp:IUPACName |
(4aS,10,10aR)-6-methoxy-11-methyl-1,2,3,4,4a,9,10,10a-octahydro-6H-10,4a-iminoethanophenanthrene
|
| gptkbp:legalStatus |
OTC (over-the-counter) in many countries
|
| gptkbp:mechanismOfAction |
NMDA receptor antagonist
norepinephrine reuptake inhibitor sigma-1 receptor agonist nicotinic acetylcholine receptor antagonist |
| gptkbp:meltingPoint |
111–112 °C
|
| gptkbp:metabolism |
gptkb:CYP2D6
gptkb:dextrorphan |
| gptkbp:molecularWeight |
271.4 g/mol
|
| gptkbp:pregnancyCategory |
C (US)
|
| gptkbp:PubChem_CID |
5360696
CHEMBL651 |
| gptkbp:relatedTo |
gptkb:codeine
gptkb:levomethorphan opioid |
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
nausea
dizziness drowsiness hallucinations (at high doses) |
| gptkbp:solubility |
slightly soluble in water
|
| gptkbp:toxicity |
can cause serotonin syndrome in combination with other serotonergic drugs
can cause dissociative effects at high doses |
| gptkbp:UNII |
7355X3RO96
|
| gptkbp:usedFor |
cough suppressant
component in cold medications |
| gptkbp:bfsParent |
gptkb:(−)-levomethorphan
|
| gptkbp:bfsLayer |
8
|