|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:NMDA_receptor_antagonist
gptkb:antitussive
gptkb:dissociative_drug
|
|
gptkbp:abusePotential
|
yes
|
|
gptkbp:ATCCode
|
R05DA09
|
|
gptkbp:brand
|
gptkb:Coricidin
gptkb:Delsym
gptkb:NyQuil
gptkb:Robitussin
gptkb:Vicks_44
|
|
gptkbp:CASNumber
|
125-71-3
|
|
gptkbp:chemicalFormula
|
C18H25NO
|
|
gptkbp:chirality
|
dextrorotatory
|
|
gptkbp:combines
|
bupropion (for depression)
quinidine (for pseudobulbar affect)
|
|
gptkbp:developedBy
|
gptkb:Hoffmann-La_Roche
|
|
gptkbp:discoveredBy
|
1953
|
|
gptkbp:eliminationHalfLife
|
3–6 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasInChIKey
|
MKXZASYAUGDDCJ-UHFFFAOYSA-N
|
|
gptkbp:hasSMILES
|
COc1ccc2CC3CCN(C)CC3c2c1
|
|
gptkbp:IUPACName
|
(4aS,10,10aR)-6-methoxy-11-methyl-1,2,3,4,4a,9,10,10a-octahydro-6H-10,4a-iminoethanophenanthrene
|
|
gptkbp:legalStatus
|
OTC (over-the-counter) in many countries
|
|
gptkbp:mechanismOfAction
|
gptkb:norepinephrine_reuptake_inhibitor
gptkb:NMDA_receptor_antagonist
sigma-1 receptor agonist
nicotinic acetylcholine receptor antagonist
|
|
gptkbp:meltingPoint
|
111–112 °C
|
|
gptkbp:metabolism
|
gptkb:CYP2D6
gptkb:dextrorphan
|
|
gptkbp:molecularWeight
|
271.4 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
5360696
CHEMBL651
|
|
gptkbp:relatedTo
|
gptkb:codeine
gptkb:levomethorphan
gptkb:opioid
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
dizziness
drowsiness
hallucinations (at high doses)
|
|
gptkbp:solubility
|
slightly soluble in water
|
|
gptkbp:toxicity
|
can cause serotonin syndrome in combination with other serotonergic drugs
can cause dissociative effects at high doses
|
|
gptkbp:UNII
|
7355X3RO96
|
|
gptkbp:usedFor
|
gptkb:cough_suppressant
component in cold medications
|
|
gptkbp:bfsParent
|
gptkb:(−)-levomethorphan
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
(+)-dextromethorphan
|