|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:affiliatedWith
|
class-I aminoacyl-tRNA synthetases
|
|
gptkbp:alternativeName
|
ValRS
valine-tRNA ligase
|
|
gptkbp:associatedWith
|
neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy (VARS-related)
|
|
gptkbp:biologicalProcess
|
translator
aminoacyl-tRNA ligase activity
|
|
gptkbp:catalyzes
|
attachment of valine to tRNA(Val)
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
|
|
gptkbp:EC_number
|
6.1.1.9
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
eukaryotes
|
|
gptkbp:gene
|
VARS
|
|
gptkbp:gene_symbol_(E._coli)
|
valS
|
|
gptkbp:GO_term
|
GO:0004832
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
valyl-tRNA synthetase
|
|
gptkbp:inhibitedBy
|
mupirocin (in some bacteria)
|
|
gptkbp:InterPro
|
IPR002300
|
|
gptkbp:OMIM_ID_(human)
|
192150
|
|
gptkbp:product
|
gptkb:AMP
pyrophosphate
valyl-tRNA(Val)
|
|
gptkbp:proteinFamily
|
PF00133
|
|
gptkbp:requires
|
Mg2+
|
|
gptkbp:structure
|
homodimer (in many species)
|
|
gptkbp:substrate
|
gptkb:ATP
valine
tRNA(Val)
|
|
gptkbp:UniProt_ID_(E._coli)
|
P07118
|
|
gptkbp:UniProtID
|
P26640
|
|
gptkbp:bfsParent
|
gptkb:class_I_aminoacyl-tRNA_synthetase
|
|
gptkbp:bfsLayer
|
7
|