|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
TyrRS
YARS
tyrosine--tRNA ligase
|
|
gptkbp:associatedWith
|
Charcot-Marie-Tooth disease (YARS mutations)
|
|
gptkbp:biologicalProcess
|
translator
aminoacyl-tRNA biosynthesis
tyrosine-tRNA ligase activity
|
|
gptkbp:catalyzes
|
attachment of tyrosine to tRNA(Tyr)
|
|
gptkbp:conservedIn
|
gptkb:HIGH_motif
gptkb:KMSKS_motif
|
|
gptkbp:EC_number
|
6.1.1.1
|
|
gptkbp:expressedIn
|
all tissues
|
|
gptkbp:firstDescribed
|
1950s
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
eukaryotes
|
|
gptkbp:function
|
aminoacylation of tRNA with tyrosine
|
|
gptkbp:gene
|
YARS
|
|
gptkbp:gene_location_(human)
|
chromosome 1p35.1
|
|
gptkbp:gene_symbol_(yeast)
|
TYS1
|
|
gptkbp:homolog_in_human
|
YARS
|
|
gptkbp:homolog_in_yeast
|
TYS1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
tyrosyl-tRNA synthetase
|
|
gptkbp:inhibitedBy
|
resveratrol
|
|
gptkbp:interactsWith
|
EF-1A
tRNA(Tyr) anticodon loop
|
|
gptkbp:location
|
gptkb:cytoplasm
mitochondria
|
|
gptkbp:molecularWeight
|
~58 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause peripheral neuropathy
|
|
gptkbp:ortholog_in_Drosophila
|
Aats-tyr
|
|
gptkbp:orthologInMouse
|
Yars
|
|
gptkbp:PDB
|
1H3E
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
|
|
gptkbp:product
|
gptkb:AMP
pyrophosphate
tyrosyl-tRNA(Tyr)
|
|
gptkbp:proteinFamily
|
gptkb:class_I_aminoacyl-tRNA_synthetase
|
|
gptkbp:required_cofactor
|
Mg2+
|
|
gptkbp:requires
|
protein synthesis
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:ATP
gptkb:L-tyrosine
tRNA(Tyr)
|
|
gptkbp:UniProt_ID_(E._coli)
|
P00960
|
|
gptkbp:UniProtID
|
P54577
|
|
gptkbp:bfsParent
|
gptkb:class_II_aminoacyl-tRNA_synthetase
gptkb:class_I_aminoacyl-tRNA_synthetase
|
|
gptkbp:bfsLayer
|
7
|