Statements (18)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
scientific theory
|
| gptkbp:appliesTo |
gptkb:retinoblastoma
tumor suppressor genes hereditary cancer |
| gptkbp:describes |
mechanism of tumor suppressor gene inactivation
|
| gptkbp:field |
genetics
oncology |
| gptkbp:firstHit |
germline mutation
|
| https://www.w3.org/2000/01/rdf-schema#label |
two-hit hypothesis
|
| gptkbp:influenced |
cancer genetics research
|
| gptkbp:proposedBy |
1971
Alfred Knudson |
| gptkbp:relatedTo |
gptkb:Knudson_hypothesis
loss of heterozygosity |
| gptkbp:secondHit |
somatic mutation
|
| gptkbp:state |
both alleles of a tumor suppressor gene must be inactivated for cancer to develop
|
| gptkbp:bfsParent |
gptkb:Alfred_G._Knudson
|
| gptkbp:bfsLayer |
7
|