tryptophanyl-tRNA synthetase

URI: https://gptkb.org/entity/tryptophanyl-tRNA_synthetase
GPTKB entity
Statements (37)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:affiliatedWith aminoacyl-tRNA synthetase family
gptkbp:alternativeName TrpRS
WARS
gptkbp:associatedWith Charcot-Marie-Tooth disease (some variants)
gptkbp:biologicalProcess ligase activity
gptkbp:catalyzes attachment of tryptophan to tRNA(Trp)
gptkbp:cellularComponent gptkb:cytoplasm
mitochondrion
gptkbp:EC_number 6.1.1.2
gptkbp:firstDescribed 1950s
gptkbp:foundIn gptkb:Bacteria
archaea
eukaryotes
gptkbp:function aminoacylation of tRNA(Trp)
gptkbp:gene WARS
gptkbp:gene_symbol_(yeast) gptkb:TRP1
gptkbp:GO_term GO:0004820
https://www.w3.org/2000/01/rdf-schema#label tryptophanyl-tRNA synthetase
gptkbp:inhibitedBy indolmycin
gptkbp:locatedOnChromosome gptkb:14q32.2
gptkbp:OMIM 191050
gptkbp:organism-specific_variant mitochondrial tryptophanyl-tRNA synthetase
gptkbp:PDB 1MAU
gptkbp:product gptkb:AMP
pyrophosphate
tryptophanyl-tRNA(Trp)
gptkbp:required_cofactor Mg2+
gptkbp:requires protein biosynthesis
gptkbp:structure homodimer (in many species)
gptkbp:substrate gptkb:ATP
tryptophan
tRNA(Trp)
gptkbp:UniProtID P23381
gptkbp:bfsParent gptkb:class_II_aminoacyl-tRNA_synthetase
gptkb:class_I_aminoacyl-tRNA_synthetase
gptkbp:bfsLayer 7