thyroid hormone receptor beta

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alias	gptkb:NR1A2 gptkb:c-erbA-beta ERBA2 THRbeta
gptkbp:alternativeSplicing	produces multiple isoforms
gptkbp:associatedWith	gptkb:thyroid_hormone_resistance_syndrome
gptkbp:biologicalProcess	transcription regulation DNA binding hormone binding
gptkbp:discoveredBy	1986
gptkbp:Entrez_Gene_ID	7068
gptkbp:expressedIn	gptkb:kidney brain heart liver
gptkbp:function	gptkb:transcription_factor gptkb:nuclear_receptor
gptkbp:gene	gptkb:THRB
gptkbp:geneType	protein-coding
gptkbp:HGNC_ID	HGNC:11797
gptkbp:interactsWith	coactivators corepressors retinoid X receptor
gptkbp:length	461
gptkbp:ligand	gptkb:triiodothyronine_(T3) thyroxine (T4)
gptkbp:locatedIn	gptkb:nucleus
gptkbp:locatedOnChromosome	3p24.2
gptkbp:member	nuclear receptor superfamily
gptkbp:molecularWeight	~54 kDa
gptkbp:OMIM	190160
gptkbp:orthologInMouse	Thrb
gptkbp:pathway	gptkb:thyroid_hormone_signaling_pathway
gptkbp:PDB	1NAX 1XZX
gptkbp:regulates	development differentiation gene expression metabolism cholesterol metabolism cardiac function
gptkbp:subcellularLocation	gptkb:nucleus gptkb:cytoplasm
gptkbp:UniProtID	P10828
gptkbp:bfsParent	gptkb:THR5
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	thyroid hormone receptor beta