thyroid hormone receptor beta

URI: https://gptkb.org/entity/thyroid_hormone_receptor_beta
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alias gptkb:NR1A2
gptkb:c-erbA-beta
ERBA2
THRbeta
gptkbp:alternativeSplicing produces multiple isoforms
gptkbp:associatedWith gptkb:thyroid_hormone_resistance_syndrome
gptkbp:biologicalProcess transcription regulation
DNA binding
hormone binding
gptkbp:discoveredBy 1986
gptkbp:Entrez_Gene_ID 7068
gptkbp:expressedIn gptkb:kidney
brain
heart
liver
gptkbp:function transcription factor
nuclear receptor
gptkbp:gene gptkb:THRB
gptkbp:geneType protein-coding
gptkbp:HGNC_ID HGNC:11797
https://www.w3.org/2000/01/rdf-schema#label thyroid hormone receptor beta
gptkbp:interactsWith coactivators
corepressors
retinoid X receptor
gptkbp:length 461
gptkbp:ligand gptkb:triiodothyronine_(T3)
thyroxine (T4)
gptkbp:locatedIn gptkb:nucleus
gptkbp:locatedOnChromosome 3p24.2
gptkbp:member nuclear receptor superfamily
gptkbp:molecularWeight ~54 kDa
gptkbp:OMIM 190160
gptkbp:orthologInMouse Thrb
gptkbp:pathway gptkb:thyroid_hormone_signaling_pathway
gptkbp:PDB 1NAX
1XZX
gptkbp:regulates development
differentiation
gene expression
metabolism
cholesterol metabolism
cardiac function
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:UniProtID P10828
gptkbp:bfsParent gptkb:THR5
gptkbp:bfsLayer 7