Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activeSiteResidue |
cysteine
|
| gptkbp:catalyzes |
thiolytic cleavage of acyl-CoA
|
| gptkbp:cofactor |
gptkb:Coenzyme_A
|
| gptkbp:discoveredBy |
1950s
|
| gptkbp:EC_number |
2.3.1.9
|
| gptkbp:foundIn |
gptkb:Bacteria
animals plants |
| gptkbp:gene |
gptkb:ACAA1
gptkb:ACAA2 gptkb:ACAT1 |
| gptkbp:hasIsoform |
3-ketoacyl-CoA thiolase
acetyl-CoA acetyltransferase mitochondrial thiolase peroxisomal thiolase |
| https://www.w3.org/2000/01/rdf-schema#label |
thiolase
|
| gptkbp:inhibitedBy |
CoA analogs
|
| gptkbp:involves |
fatty acid metabolism
ketone body metabolism |
| gptkbp:participatedIn |
ketogenesis
isoleucine catabolism beta-oxidation of fatty acids |
| gptkbp:PDB |
1DM3
2IBW |
| gptkbp:product |
acetyl-CoA
acetoacetate |
| gptkbp:structure |
homodimer
homotetramer |
| gptkbp:substrate |
acetoacetyl-CoA
|
| gptkbp:bfsParent |
gptkb:ACAT
|
| gptkbp:bfsLayer |
8
|