succinate dehydrogenase (complex II)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:activity	DCPIP reduction
gptkbp:alsoKnownAs	gptkb:complex_II gptkb:succinate-coenzyme_Q_reductase
gptkbp:associatedWith	gptkb:Leigh_syndrome gptkb:pheochromocytoma gptkb:mitochondrial_complex_II_deficiency paraganglioma
gptkbp:CASNumber	gptkb:9029-39-4
gptkbp:cofactor	gptkb:FAD gptkb:heme_b iron-sulfur clusters
gptkbp:component	electron transport chain citric acid cycle
gptkbp:determines	X-ray crystallography
gptkbp:EC_number	1.3.5.1
gptkbp:eukaryotePresence	yes
gptkbp:firstDescribed	1950s
gptkbp:foundIn	mitochondria
gptkbp:function	catalyzes oxidation of succinate to fumarate reduces ubiquinone to ubiquinol
gptkbp:gene	gptkb:SDHA gptkb:SDHB gptkb:SDHC gptkb:SDHD
gptkbp:GO_term	GO:0008177
https://www.w3.org/2000/01/rdf-schema#label	succinate dehydrogenase (complex II)
gptkbp:inhibitedBy	gptkb:thenoyltrifluoroacetone malonate
gptkbp:location	inner mitochondrial membrane
gptkbp:molecularWeight	~140 kDa
gptkbp:mutationAssociatedWith	tumorigenesis metabolic disorders
gptkbp:OMIM	600857
gptkbp:orthologIn	gptkb:Bacteria archaea eukaryotes
gptkbp:pathway	oxidative phosphorylation TCA cycle
gptkbp:PDB	gptkb:2H88 1ZOY
gptkbp:prokaryotePresence	yes
gptkbp:requires	aerobic respiration
gptkbp:subunit	gptkb:SDHA gptkb:SDHB gptkb:SDHC gptkb:SDHD
gptkbp:type	succinate + ubiquinone → fumarate + ubiquinol
gptkbp:UniProtID	gptkb:P31040
gptkbp:bfsParent	gptkb:SDHA gptkb:Q99643_(SDHC,_human)
gptkbp:bfsLayer	7