stearoyl-CoA desaturase-1

URI: https://gptkb.org/entity/stearoyl-CoA_desaturase-1
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:SCD1
delta-9 desaturase
gptkbp:associatedWith gptkb:non-alcoholic_fatty_liver_disease
obesity
insulin resistance
gptkbp:catalyzes desaturation of stearoyl-CoA to oleoyl-CoA
gptkbp:cofactor gptkb:NADH
oxygen
cytochrome b5
gptkbp:EC_number 1.14.19.1
gptkbp:encodedBy SCD gene
gptkbp:foundIn gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:function biosynthesis of monounsaturated fatty acids
gptkbp:gene SCD
https://www.w3.org/2000/01/rdf-schema#label stearoyl-CoA desaturase-1
gptkbp:involves lipid metabolism
energy homeostasis
gptkbp:locatedIn gptkb:endoplasmic_reticulum
gptkbp:locatedOnChromosome 10q24.31
gptkbp:OMIM 604031
gptkbp:product oleoyl-CoA
gptkbp:regulates regulated by insulin
regulated by dietary factors
regulated by leptin
gptkbp:structure integral membrane protein
gptkbp:substrate stearoyl-CoA
gptkbp:target metabolic disease therapy
gptkbp:UniProtID gptkb:O00767
gptkbp:bfsParent gptkb:SCD1
gptkbp:bfsLayer 7