Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genomics technique
|
| gptkbp:analyzes |
open chromatin regions
|
| gptkbp:appliesTo |
cancer research
developmental biology immunology neuroscience |
| gptkbp:developedBy |
gptkb:ATAC-seq
|
| gptkbp:enables |
identification of regulatory elements
study of gene regulation cell type identification identification of rare cell types integration with other single-cell data mapping of regulatory landscapes study of cell state transitions study of chromatin dynamics study of transcription factor binding |
| gptkbp:firstPublished |
2015
|
| gptkbp:fullName |
single-cell Assay for Transposase-Accessible Chromatin using sequencing
|
| https://www.w3.org/2000/01/rdf-schema#label |
single-cell ATAC-seq
|
| gptkbp:limitation |
high cost
sparse data complex data analysis technical noise |
| gptkbp:protocolVariants |
combinatorial indexing
droplet-based methods microfluidics-based methods plate-based methods |
| gptkbp:relatedTo |
gptkb:single-cell_RNA-seq
single-cell multi-omics |
| gptkbp:requires |
bioinformatics analysis
sequencing platforms cell barcoding |
| gptkbp:resolution |
single-cell
|
| gptkbp:supportsProtocol |
data analysis
sequencing library preparation PCR amplification high-throughput sequencing cell lysis tagmentation nuclei isolation transposase Tn5 |
| gptkbp:type |
sequencing reads
chromatin accessibility profiles |
| gptkbp:usedFor |
cellular heterogeneity analysis
chromatin accessibility profiling epigenomic analysis |
| gptkbp:bfsParent |
gptkb:ATAC-seq
|
| gptkbp:bfsLayer |
7
|