|
gptkbp:instance_of
|
gptkb:software
|
|
gptkbp:activities
|
HMG-Co A reductase inhibitor
|
|
gptkbp:appointed_by
|
oral tablet
|
|
gptkbp:approves
|
gptkb:2003
gptkb:FDA
|
|
gptkbp:brand
|
gptkb:Crestor
Ezallor
Rosuvastatin
|
|
gptkbp:clinical_trial
|
JUPITER trial
METEOR trial
CANTOS trial
CORONA trial
REVEAL trial
|
|
gptkbp:contraindication
|
pregnancy
breastfeeding
active liver disease
|
|
gptkbp:dosage_form
|
gptkb:tablet
|
|
gptkbp:has_ability
|
10 mg
5 mg
20 mg
40 mg
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
rosuvastatin calcium
|
|
gptkbp:ingredients
|
C22 H28 F N3 O6 S
|
|
gptkbp:interacts_with
|
gptkb:cyclosporine
gptkb:warfarin
antacids
gemfibrozil
|
|
gptkbp:is_available_in
|
tablets
combination products
|
|
gptkbp:is_available_on
|
generic
|
|
gptkbp:is_used_for
|
lowering cholesterol
|
|
gptkbp:lifespan
|
19 hours
|
|
gptkbp:manufacturer
|
gptkb:temple
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pharmacokinetics
|
excreted in urine
high bioavailability
food does not affect absorption
excreted in feces
|
|
gptkbp:side_effect
|
headache
muscle pain
nausea
abdominal pain
constipation
|
|
gptkbp:suitable_for
|
gptkb:familial_hypercholesterolemia
hyperlipidemia
cardiovascular disease prevention
|
|
gptkbp:bfsParent
|
gptkb:Crestor
|
|
gptkbp:bfsLayer
|
6
|