Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
PC
|
| gptkbp:catalyzes |
conversion of pyruvate to oxaloacetate
|
| gptkbp:cofactor |
gptkb:biotin
|
| gptkbp:deficiencyCauses |
lactic acidosis
neurological dysfunction |
| gptkbp:discoveredBy |
gptkb:Fritz_Lipmann
|
| gptkbp:discoveredIn |
1959
|
| gptkbp:EC_number |
6.4.1.1
|
| gptkbp:foundIn |
mitochondria
|
| gptkbp:gene |
PC
|
| https://www.w3.org/2000/01/rdf-schema#label |
pyruvate carboxylase enzyme
|
| gptkbp:involves |
gluconeogenesis
anaplerotic reactions |
| gptkbp:locatedOnChromosome |
11q13.2 (human)
|
| gptkbp:molecularWeight |
~130 kDa (monomer)
|
| gptkbp:presentIn |
gptkb:Bacteria
animals humans plants |
| gptkbp:regulates |
acetyl-CoA
|
| gptkbp:requires |
gptkb:ATP
CO2 Mg2+ |
| gptkbp:structure |
tetramer
|
| gptkbp:UniProtID |
P11498 (human)
|
| gptkbp:bfsParent |
gptkb:pyruvate_carboxylase_deficiency
|
| gptkbp:bfsLayer |
8
|