DB13162

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 2020
gptkbp:ATCCode J05AB16
gptkbp:bioavailability low (IV only)
gptkbp:brand gptkb:Veklury
gptkbp:CASNumber 1809249-37-3
gptkbp:clinicalTrialPhase Phase 3
gptkbp:contraindication hypersensitivity to remdesivir
gptkbp:developer gptkb:Gilead_Sciences
gptkbp:drugClass antiviral drug
gptkbp:eliminationHalfLife 1 hour (remdesivir), 25 hours (GS-441524)
gptkbp:form solution for injection
lyophilized powder
gptkbp:hasBoxedWarning none
gptkbp:hasEMAApprovalDate 2020-07-03
gptkbp:hasFDAApprovalDate 2020-10-22
gptkbp:hasInChIKey RWWYLEGWBNMMLJ-YSOARWBDSA-N
gptkbp:hasMolecularFormula C27H35N6O8P
gptkbp:hasOrphanDrugStatus granted (later rescinded)
gptkbp:hasPatentHolder gptkb:Gilead_Sciences
gptkbp:hasPharmacokinetics extensively metabolized
gptkbp:hasSMILES CC(C)[C@@H](NC(=O)[C@@H](COP(=O)(OCC1=CN=CN1)[O-])N)C(=O)N[C@@H](C)C(=O)O
gptkbp:hasStorageCondition store at 20°C to 25°C
gptkbp:hasUNII 53J0A36V2L
https://www.w3.org/2000/01/rdf-schema#label DB13162
gptkbp:indication gptkb:COVID-19
gptkb:Ebola_virus_infection_(investigational)
gptkbp:legalStatus prescription only
patented
gptkbp:mechanismOfAction RNA polymerase inhibitor
gptkbp:metabolism hydrolysis and phosphorylation
gptkbp:molecularWeight 602.6 g/mol
gptkbp:name gptkb:Remdesivir
gptkbp:pregnancyCategory Not assigned
gptkbp:PubChem_CID gptkb:DB13162
121304016
CHEMBL2016761
D11472
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect nausea
elevated liver enzymes
hypersensitivity
gptkbp:status FDA approved
EMA approved
gptkbp:structureType prodrug
gptkbp:synonym gptkb:GS-5734
gptkbp:target RNA-dependent RNA polymerase
gptkbp:therapeuticArea gptkb:disease
gptkbp:bfsParent gptkb:picrotoxin
gptkbp:bfsLayer 7