orotidine 5'-phosphate decarboxylase
GPTKB entity
Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
ODCase
OMP decarboxylase |
| gptkbp:associatedWith |
orotic aciduria (deficiency in humans)
|
| gptkbp:biologicalProcess |
de novo UMP biosynthetic process
|
| gptkbp:catalyzes |
decarboxylation of orotidine 5'-monophosphate to uridine 5'-monophosphate
|
| gptkbp:cellular_component_(GO) |
cytosol
|
| gptkbp:cofactor |
none required
|
| gptkbp:discoveredBy |
1950s
|
| gptkbp:EC_number |
4.1.1.23
|
| gptkbp:foundIn |
all domains of life
|
| gptkbp:gene |
UMPS
|
| https://www.w3.org/2000/01/rdf-schema#label |
orotidine 5'-phosphate decarboxylase
|
| gptkbp:molecular_function_(GO) |
orotidine-5'-phosphate decarboxylase activity
|
| gptkbp:pathway |
pyrimidine biosynthesis
|
| gptkbp:PDB |
yes
|
| gptkbp:product |
uridine 5'-monophosphate
|
| gptkbp:reaction_rate_enhancement |
increases rate by 10^17 fold
|
| gptkbp:remarkable_property |
one of the most efficient enzymes known
|
| gptkbp:structure |
homodimer in many species
|
| gptkbp:substrate |
orotidine 5'-monophosphate
|
| gptkbp:bfsParent |
gptkb:pyrF_(in_E._coli)
gptkb:TIM_barrel |
| gptkbp:bfsLayer |
8
|