orotate phosphoribosyltransferase
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
OPRTase
orotate phosphoribosyltransferase domain |
| gptkbp:catalyzes |
orotate + PRPP → orotidine-5'-monophosphate + pyrophosphate
|
| gptkbp:cofactor |
Mg2+
|
| gptkbp:deficiencyCauses |
orotic aciduria
|
| gptkbp:EC_number |
2.4.2.10
|
| gptkbp:foundIn |
gptkb:Bacteria
archaea eukaryotes |
| gptkbp:gene |
UMPS (in humans)
|
| gptkbp:GO_term |
GO:0004588
|
| https://www.w3.org/2000/01/rdf-schema#label |
orotate phosphoribosyltransferase
|
| gptkbp:involvedIn |
pyrimidine biosynthesis
|
| gptkbp:locatedIn |
cytosol (in eukaryotes)
|
| gptkbp:partOf |
UMP synthase (in humans)
|
| gptkbp:product |
pyrophosphate
orotidine-5'-monophosphate (OMP) |
| gptkbp:structure |
homodimer (in many species)
|
| gptkbp:substrate |
orotate
phosphoribosyl pyrophosphate (PRPP) |
| gptkbp:bfsParent |
gptkb:URA5
|
| gptkbp:bfsLayer |
7
|