nucleoside reverse transcriptase inhibitor
GPTKB entity
Statements (65)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:immunotherapy
|
| gptkbp:administered_by |
oral medication
|
| gptkbp:available_on |
generic medication
|
| gptkbp:can_be_combined_with |
integrase inhibitors
|
| gptkbp:can_cause |
gptkb:lipodystrophy
lactic acidosis |
| gptkbp:developed_by |
gptkb:1980s
pharmaceutical companies |
| https://www.w3.org/2000/01/rdf-schema#label |
nucleoside reverse transcriptase inhibitor
|
| gptkbp:includes |
gptkb:abacavir
gptkb:lamivudine gptkb:tenofovir gptkb:zidovudine |
| gptkbp:ingredients |
infectious disease specialists
|
| gptkbp:interacts_with |
protease inhibitors
non-nucleoside reverse transcriptase inhibitors |
| gptkbp:is_associated_with |
improved quality of life
adverse drug reactions reduced transmission risk improved life expectancy reduced morbidity |
| gptkbp:is_considered |
treatment guidelines
|
| gptkbp:is_effective_against |
HIV latent reservoirs
|
| gptkbp:is_evaluated_by |
cost-effectiveness
efficacy long-term effects drug resistance safety profile |
| gptkbp:is_monitored_by |
viral load
CD4 count |
| gptkbp:is_part_of |
gptkb:immunotherapy
combination therapy global health initiatives treatment regimens HIV care continuum HIV treatment guidelines HAART regimen |
| gptkbp:is_recommended_for |
high-risk populations
|
| gptkbp:is_regulated_by |
gptkb:FDA
gptkb:EMA |
| gptkbp:is_studied_for |
gptkb:cancer_treatment
HCV treatment co-infections other viral infections |
| gptkbp:is_subject_to |
clinical trials
|
| gptkbp:is_used_in |
clinical practice
HIV prevention strategies post-exposure prophylaxis treatment-naive patients pre-exposure prophylaxis pediatric HIV treatment treatment-experienced patients |
| gptkbp:mechanism_of_action |
inhibits reverse transcriptase
|
| gptkbp:requires |
adherence to therapy
|
| gptkbp:side_effect |
gptkb:anemia
fatigue headache nausea |
| gptkbp:suitable_for |
pregnant women without monitoring
|
| gptkbp:targets |
gptkb:HIV-1
gptkb:HIV-2 |
| gptkbp:used_for |
treatment of HIV
|
| gptkbp:bfsParent |
gptkb:azidothymidine_(AZT)
gptkb:Biktarvy |
| gptkbp:bfsLayer |
5
|