|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:monoacylglycerol_lipase
gptkb:MAGL
monoglyceridase
|
|
gptkbp:associatedWith
|
gptkb:cancer
obesity
neurological disorders
|
|
gptkbp:catalyzes
|
hydrolysis of monoglycerides
|
|
gptkbp:cofactor
|
none required
|
|
gptkbp:EC_number
|
3.1.1.23
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:small_intestine
gptkb:testis
brain
heart
liver
adipose tissue
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:function
|
breakdown of monoacylglycerols to free fatty acids and glycerol
|
|
gptkbp:gene
|
gptkb:MGLL
|
|
gptkbp:gene_location_(human)
|
gptkb:chromosome_3q21.3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
monoglyceride lipase
|
|
gptkbp:inhibitedBy
|
gptkb:JZL184
gptkb:KML29
gptkb:URB602
|
|
gptkbp:involves
|
lipid metabolism
endocannabinoid signaling
|
|
gptkbp:location
|
gptkb:cell_membrane
cytosol
|
|
gptkbp:molecularWeight
|
33 kDa
|
|
gptkbp:orthologInMouse
|
Mgll
|
|
gptkbp:orthologInZebrafish
|
mgll
|
|
gptkbp:PDB
|
gptkb:3PE6
3JW8
3VZB
|
|
gptkbp:product
|
gptkb:arachidonic_acid
glycerol
|
|
gptkbp:regulates
|
inhibited by phosphorylation
regulated by endocannabinoid levels
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:2-arachidonoylglycerol
|
|
gptkbp:UniProtID
|
gptkb:Q99685
|
|
gptkbp:bfsParent
|
gptkb:monoacylglycerol_lipase
|
|
gptkbp:bfsLayer
|
7
|