|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
MetH
5-methyltetrahydrofolate-homocysteine methyltransferase
|
|
gptkbp:associatedWith
|
hyperhomocysteinemia
cardiovascular disease (when deficient)
|
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gptkbp:biologicalProcess
|
transferase activity
|
|
gptkbp:catalyzes
|
methylation of homocysteine to methionine
|
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gptkbp:cofactor
|
vitamin B12
methylcobalamin
|
|
gptkbp:deficiencyCauses
|
gptkb:homocystinuria
megaloblastic anemia
|
|
gptkbp:EC_number
|
2.1.1.13
|
|
gptkbp:encodedBy
|
MTR gene (in humans)
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
humans
|
|
gptkbp:gene
|
gptkb:MTR
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
methionine synthase
|
|
gptkbp:inhibitedBy
|
nitrous oxide
|
|
gptkbp:locatedIn
|
gptkb:cytoplasm
|
|
gptkbp:ortholog_in_E._coli
|
MetH
|
|
gptkbp:ortholog_in_humans
|
gptkb:MTR
|
|
gptkbp:participatedIn
|
one-carbon metabolism
methionine biosynthesis
|
|
gptkbp:product
|
methionine
tetrahydrofolate
|
|
gptkbp:requires
|
cobalamin
|
|
gptkbp:structure
|
multi-domain protein
|
|
gptkbp:substrate
|
homocysteine
5-methyltetrahydrofolate
|
|
gptkbp:UniProtID
|
P42898
|
|
gptkbp:bfsParent
|
gptkb:Methyltetrahydrofolate
|
|
gptkbp:bfsLayer
|
7
|