|
gptkbp:instanceOf
|
gptkb:antibiotic
lincosamide antibiotic
|
|
gptkbp:approvedBy
|
1964
|
|
gptkbp:ATCCode
|
J01FF02
|
|
gptkbp:CASNumber
|
154-21-2
|
|
gptkbp:chemicalFormula
|
C18H34N2O6S
|
|
gptkbp:contraindication
|
hypersensitivity to lincomycin
|
|
gptkbp:discoveredBy
|
gptkb:Upjohn_Company
|
|
gptkbp:eliminationHalfLife
|
5.4 hours
|
|
gptkbp:excretion
|
renal
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
lincomycin
|
|
gptkbp:indication
|
serious infections by susceptible Gram-positive bacteria
|
|
gptkbp:KEGGID
|
gptkb:D08106
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits protein synthesis
|
|
gptkbp:meltingPoint
|
151–153 °C
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:molecularWeight
|
406.54 g/mol
|
|
gptkbp:notEffectiveAgainst
|
Gram-negative bacteria
|
|
gptkbp:pregnancyCategory
|
C
|
|
gptkbp:producedBy
|
Streptomyces lincolnensis
|
|
gptkbp:PubChem_CID
|
CHEMBL1387
16736197
3000348
DB01627
|
|
gptkbp:relatedTo
|
gptkb:clindamycin
|
|
gptkbp:riskFactor
|
gptkb:Clostridioides_difficile_infection
|
|
gptkbp:routeOfAdministration
|
oral
intramuscular
intravenous
|
|
gptkbp:sideEffect
|
nausea
diarrhea
rash
inflammatory bowel disease
|
|
gptkbp:solubility
|
soluble in water
|
|
gptkbp:target
|
50S ribosomal subunit
|
|
gptkbp:UNII
|
Q364AIF9D8
|
|
gptkbp:usedFor
|
bacterial infections
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
no
|
|
gptkbp:bfsParent
|
gptkb:J01CG01
gptkb:lincosamides
gptkb:Clindamycin
gptkb:Streptomyces
gptkb:clindamycin
|
|
gptkbp:bfsLayer
|
7
|