lamotrigine

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instance_of gptkb:Antihero
gptkbp:approves gptkb:1994
gptkb:FDA
gptkbp:available_on generic drug
gptkbp:brand Lamictal
gptkbp:category gptkb:C
gptkbp:chemical_formula C9 H7 Cl2 N5
gptkbp:clinical_trial Phase III
gptkbp:contraindication hypersensitivity
severe liver impairment
gptkbp:developed_by gptkb:Glaxo_Smith_Kline
gptkbp:dosage_form 100-200 mg daily
25-50 mg daily for maintenance
initial dose 25 mg daily
gptkbp:drug_interactions gptkb:valproate
gptkb:carbamazepine
oral contraceptives
gptkbp:excretion urine
gptkbp:formulation gptkb:tablet
extended-release tablet
chewable tablet
dispersible tablet
https://www.w3.org/2000/01/rdf-schema#label lamotrigine
gptkbp:is_monitored_by skin reactions
liver function tests
serum levels
gptkbp:lifespan 25 hours
gptkbp:mechanism_of_action inhibits voltage-gated sodium channels
gptkbp:metabolism liver
gptkbp:provides_guidance_on gptkb:National_Institute_for_Health_and_Care_Excellence
gptkb:American_Psychiatric_Association
gptkb:American_Academy_of_Neurology
gptkbp:route_of_administration oral
gptkbp:side_effect gptkb:depression
anxiety
dizziness
fatigue
headache
nausea
vomiting
rash
ataxia
drowsiness
insomnia
blurred vision
suicidal thoughts
tremor
aseptic meningitis
gptkbp:used_for gptkb:epilepsy
bipolar disorder
gptkbp:bfsParent gptkb:carbamazepine
gptkbp:bfsLayer 5