Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:affects |
HDL metabolism
LDL metabolism VLDL metabolism |
| gptkbp:alternativeName |
gptkb:LIPC
HL |
| gptkbp:associatedWith |
atherosclerosis
dyslipidemia |
| gptkbp:biologicalProcess |
phospholipase activity
triglyceride lipase activity |
| gptkbp:cofactor |
requires heparan sulfate proteoglycans for binding
|
| gptkbp:EC_number |
3.1.1.3
|
| gptkbp:expressedIn |
gptkb:hepatocytes
|
| gptkbp:foundIn |
liver
|
| gptkbp:function |
hydrolyzes phospholipids
hydrolyzes triglycerides |
| gptkbp:gene |
gptkb:LIPC
|
| https://www.w3.org/2000/01/rdf-schema#label |
hepatic lipase
|
| gptkbp:involves |
lipid metabolism
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_15
|
| gptkbp:location |
extracellular space
surface of liver sinusoidal endothelial cells |
| gptkbp:product |
glycerol
free fatty acids |
| gptkbp:regulates |
regulated by androgens
regulated by estrogens regulated by insulin |
| gptkbp:significance |
mutations can cause hepatic lipase deficiency
|
| gptkbp:substrate |
phospholipids
triglycerides |
| gptkbp:UniProtID |
P11150
|
| gptkbp:bfsParent |
gptkb:LIPC
|
| gptkbp:bfsLayer |
8
|