|
gptkbp:instanceOf
|
gptkb:anticoagulant
low molecular weight heparin
|
|
gptkbp:antidote
|
gptkb:protamine_sulfate
|
|
gptkbp:approvalYear
|
1993
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
B01AB05
|
|
gptkbp:biosimilar
|
yes
|
|
gptkbp:brand
|
gptkb:Lovenox
gptkb:Clexane
|
|
gptkbp:chemicalFormula
|
C26H40N2O36S5
|
|
gptkbp:contraindication
|
history of heparin-induced thrombocytopenia
active major bleeding
|
|
gptkbp:cost
|
varies by country and brand
|
|
gptkbp:discoveredBy
|
gptkb:Sanofi
|
|
gptkbp:drugClass
|
antithrombotic agent
|
|
gptkbp:eliminationHalfLife
|
4.5 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:genericName
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
enoxaparin
|
|
gptkbp:interactsWith
|
gptkb:SSRIs
gptkb:NSAIDs
gptkb:SNRIs
antiplatelet drugs
other anticoagulants
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits factor Xa
inhibits thrombin (factor IIa)
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
4500 Da (average)
|
|
gptkbp:monitors
|
anti-Xa levels (in special cases)
|
|
gptkbp:origin
|
derived from porcine intestinal mucosa
|
|
gptkbp:pregnancyCategory
|
B
can be used in pregnancy
|
|
gptkbp:riskFactor
|
spinal/epidural hematoma
|
|
gptkbp:routeOfAdministration
|
subcutaneous injection
intravenous injection
|
|
gptkbp:sideEffect
|
bleeding
injection site reaction
thrombocytopenia
|
|
gptkbp:storage
|
room temperature
|
|
gptkbp:usedFor
|
gptkb:acute_coronary_syndrome
treatment of deep vein thrombosis
treatment of pulmonary embolism
prevention of deep vein thrombosis
prevention of pulmonary embolism
|
|
gptkbp:usedIn
|
gptkb:hospital
outpatient setting
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:heparin
gptkb:Clexane
|
|
gptkbp:bfsLayer
|
6
|