|
gptkbp:instanceOf
|
gptkb:chemical_compound
antifungal medication
|
|
gptkbp:administeredBy
|
oral route
|
|
gptkbp:approvalYear
|
1958
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
D01BA01
|
|
gptkbp:CASNumber
|
126-07-8
|
|
gptkbp:category
|
gptkb:antibiotic
natural product
antifungal
|
|
gptkbp:contraindication
|
liver failure
porphyria
|
|
gptkbp:discoveredBy
|
Oxford researchers
|
|
gptkbp:discoveredIn
|
1939
|
|
gptkbp:drugInteraction
|
gptkb:beer
gptkb:warfarin
barbiturates
oral contraceptives
|
|
gptkbp:eliminationHalfLife
|
9-24 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:hasMolecularFormula
|
C17H17ClO6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
griseofulvin
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
binds to fungal microtubules
inhibits fungal mitosis
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
352.77 g/mol
|
|
gptkbp:notEffectiveAgainst
|
bacterial infections
systemic mycoses
Candida infections
|
|
gptkbp:origin
|
Penicillium griseofulvum
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:pregnancyWarning
|
may cause fetal harm
|
|
gptkbp:producedBy
|
Penicillium species
|
|
gptkbp:PubChem_CID
|
441140
DB00400
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
headache
allergic reactions
|
|
gptkbp:synonym
|
Fulvicin
Grifulvin V
Gris-PEG
|
|
gptkbp:UNII
|
32HRV3D8BW
|
|
gptkbp:usedFor
|
gptkb:athlete's_foot
gptkb:jock_itch
onychomycosis
ringworm
treatment of dermatophytosis
|
|
gptkbp:bfsParent
|
gptkb:D01AC01
|
|
gptkbp:bfsLayer
|
7
|